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Gene Review

SCN3B  -  sodium channel, voltage gated, type III...

Homo sapiens

Synonyms: ATFB16, BRGDA7, HSA243396, KIAA1158, SCNB3, ...
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High impact information on SCN3B

  • Furthermore, we found that adenovirus-mediated transfer of SCN3B induced apoptosis when combined with anticancer agents [1].
  • The SCN3B protein appears to be localized to the endoplasmic reticulum (ER) [1].
  • Three other genes showing statistical evidence (ADH1C, SCN3B, and IMP5) were not expressed in the embryonic tissues examined here [2].

Analytical, diagnostic and therapeutic context of SCN3B

  • The results presented here suggest that SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs [1].


  1. Identification of SCN3B as a novel p53-inducible proapoptotic gene. Adachi, K., Toyota, M., Sasaki, Y., Yamashita, T., Ishida, S., Ohe-Toyota, M., Maruyama, R., Hinoda, Y., Saito, T., Imai, K., Kudo, R., Tokino, T. Oncogene (2004) [Pubmed]
  2. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts. Park, J.W., Cai, J., McIntosh, I., Jabs, E.W., Fallin, M.D., Ingersoll, R., Hetmanski, J.B., Vekemans, M., Attie-Bitach, T., Lovett, M., Scott, A.F., Beaty, T.H. J. Med. Genet. (2006) [Pubmed]
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