Gene Review:
KIAA1524 - KIAA1524
Homo sapiens
Synonyms:
CIP2A, Cancerous inhibitor of PP2A, Protein CIP2A, p90, p90 autoantigen
- CIP2A inhibits PP2A in human malignancies. Junttila, M.R., Puustinen, P., Niemelä, M., Ahola, R., Arnold, H., Böttzauw, T., Ala-aho, R., Nielsen, C., Ivaska, J., Taya, Y., Lu, S.L., Lin, S., Chan, E.K., Wang, X.J., Grènman, R., Kast, J., Kallunki, T., Sears, R., Kähäri, V.M., Westermarck, J. Cell. (2007)
- MYC-dependent regulation and prognostic role of CIP2A in gastric cancer. Khanna, A., Böckelman, C., Hemmes, A., Junttila, M.R., Wiksten, J.P., Lundin, M., Junnila, S., Murphy, D.J., Evan, G.I., Haglund, C., Westermarck, J., Ristimäki, A. J. Natl. Cancer. Inst. (2009)
- CIP2A is associated with human breast cancer aggressivity. Côme, C., Laine, A., Chanrion, M., Edgren, H., Mattila, E., Liu, X., Jonkers, J., Ivaska, J., Isola, J., Darbon, J.M., Kallioniemi, O., Thézenas, S., Westermarck, J. Clin. Cancer. Res. (2009)
- CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Li, W., Ge, Z., Liu, C., Liu, Z., Björkholm, M., Jia, J., Xu, D. Clin. Cancer. Res. (2008)
- ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells. Khanna, A., Okkeri, J., Bilgen, T., Tiirikka, T., Vihinen, M., Visakorpi, T., Westermarck, J. PLoS. One. (2011)
- Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Laine, A., Sihto, H., Come, C., Rosenfeldt, M.T., Zwolinska, A., Niemelä, M., Khanna, A., Chan, E.K., Kähäri, V.M., Kellokumpu-Lehtinen, P.L., Sansom, O.J., Evan, G.I., Junttila, M.R., Ryan, K.M., Marine, J.C., Joensuu, H., Westermarck, J. Cancer. Discov. (2013)
- Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation. Mathiasen, D.P., Egebjerg, C., Andersen, S.H., Rafn, B., Puustinen, P., Khanna, A., Daugaard, M., Valo, E., Tuomela, S., Bøttzauw, T., Nielsen, C.F., Willumsen, B.M., Hautaniemi, S., Lahesmaa, R., Westermarck, J., Jäättelä, M., Kallunki, T. Oncogene. (2012)