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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GOLPH3  -  golgi phosphoprotein 3 (coat-protein)

Homo sapiens

Synonyms: Coat protein GPP34, GOPP1, GPP34, Golgi phosphoprotein 3, MIDAS, ...
 
 
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Disease relevance of GOLPH3

  • Chimeric synthetic peptides containing two immunodominant epitopes from the envelope gp46 and the transmembrane gp21 glycoproteins of HTLV-I virus [1].
 

High impact information on GOLPH3

  • A mass spectrometric analysis of proteins partitioning into Triton X-114 from purified hepatic Golgi apparatus (84% purity by morphometry, 122-fold enrichment over the homogenate for the Golgi marker galactosyl transferase) led to the unambiguous identification of 81 proteins including a novel Golgi-associated protein of 34 kDa (GPP34) [2].
  • Chimeric synthetic peptides from the envelope (gp46) and the transmembrane (gp21) glycoproteins for the detection of antibodies to human T-cell leukemia virus type II [3].
  • On the other hand, two other receptor-binding sites, Lys-111 to Asp-138 on gp46 (gp46-111) and Cys-400 to Leu-429 on gp21 (gp21-400), and which bound only with PG, had no cytotoxic effects on MOLT-4 cells [4].

References

  1. Chimeric synthetic peptides containing two immunodominant epitopes from the envelope gp46 and the transmembrane gp21 glycoproteins of HTLV-I virus. Hernández Marin, M., Castellanos Pentón, P., Márquez Bocalandro, Y., Pozo Peña, L., Díaz Navarro, J., González López, L.J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Proteomics characterization of abundant Golgi membrane proteins. Bell, A.W., Ward, M.A., Blackstock, W.P., Freeman, H.N., Choudhary, J.S., Lewis, A.P., Chotai, D., Fazel, A., Gushue, J.N., Paiement, J., Palcy, S., Chevet, E., Lafrenière-Roula, M., Solari, R., Thomas, D.Y., Rowley, A., Bergeron, J.J. J. Biol. Chem. (2001) [Pubmed]
  3. Chimeric synthetic peptides from the envelope (gp46) and the transmembrane (gp21) glycoproteins for the detection of antibodies to human T-cell leukemia virus type II. Hernández Marin, M., Castellanos Pentón, P., Márquez Bocalandro, Y., Pozo Peña, L., Díaz Navarro, J., González López, L.J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. HTLV type 1 envelope glycoprotein gp46 evokes necrosis by binding to receptor complex. Sagara, Y., Inoue, Y., Kojima, E., Shiraki, H., Maeda, Y. AIDS Res. Hum. Retroviruses (2000) [Pubmed]
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