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Gene Review

Map1lc3b  -  microtubule-associated protein 1 light...

Rattus norvegicus

Synonyms: Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, ...

Protein kinase A mediated phosphorylation of MAP1LC3 inhibits its participation in autophagy, and protects against dendrite retraction in genetic (mutant LRRK2) and toxin (MPP+) models of Parkinson's disease. [1]


  1. Regulation of the autophagy protein LC3 by phosphorylation. Cherra SJ, 3.r.d., Kulich, S.M., Uechi, G., Balasubramani, M., Mountzouris, J., Day, B.W., Chu, C.T. J. Cell. Biol. (2010) [Pubmed]
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