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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAP1LC3B  -  microtubule-associated protein 1 light...

Homo sapiens

Synonyms: ATG8F, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, LC3B, MAP1 light chain 3-like protein 2, ...
 
 
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High impact information on MAP1LC3B

  • RNA interference of MAP1LC3B mRNA resulted in a decrease in both endogenous MAP1LC3B-PL and MAP1LC3B [1].
  • Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes [1].
  • Although MAP1LC3A and MAP1LC3C are produced by the proteolytic cleavage after the conserved C-terminal Gly residue, like their rat counterpart, MAP1LC3B does not undergo C-terminal cleavage and exists in a single modified form [2].
  • Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B [2].
  • Protein kinase A mediated phosphorylation of MAP1LC3 inhibits its participation in autophagy, and protects against dendrite retraction in genetic (mutant LRRK2) and toxin (MPP+) models of Parkinson's disease. [3]

 

References

  1. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. Tanida, I., Ueno, T., Kominami, E. J. Biol. Chem. (2004) [Pubmed]
  2. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., Zhao, S., Liu, J.O., Yu, L. J. Biol. Chem. (2003) [Pubmed]
  3. Regulation of the autophagy protein LC3 by phosphorylation. Cherra SJ, 3.r.d., Kulich, S.M., Uechi, G., Balasubramani, M., Mountzouris, J., Day, B.W., Chu, C.T. J. Cell. Biol. (2010) [Pubmed]
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