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Gene Review:

4933415F23Rik - RIKEN cDNA 4933415F23 gene

Mus musculus

Liu, Q.R., Ramirez Gaite, M.

Marta Ramirez Gaite, Qing-Rong Liu,

Mouse 4933415F23Rik gene encodes Thop protein(NP_080022) with 153 amino acid sequence. Its transcript (NM_025746) is predominantly expressed in testis [1].
Thop protein is a novel protein phosphatase 1 regulatory subunit that contains protein phosphotase 1 (PP1) binding mortifs (RVYFE) of Ppp1r14 family members whose PP1 inhibitory activity is activated by PKC [1].
Unlike other Ppp1r14 gene family members with 4 exons, 4933415F23Rik gene contains only a single exon at chromosome 1A4 locus [1].
4933415F23Rik gene sequence is most homologous (75% amino acid identity) to Phi (Ppp1r14b) with acidic isoelectric point (pI=4.42) [1].
However, 4933415F23Rik gene product lost its PKC phosphorylation site (KIIVK) in the context of conserved PKC phosphorylation consensus sequence of Phi (KITVK) in which Thr residue is conserved in all other gene family members, i.e. Kepi, Cpi and Gbpi [1]. The PP1 regulatory function of Thop may not be activated by PKC.
4933415F23Rik gene is associated with the innate immune response by whole genome association (WGA) mapping of cytokine concentrations of 16 inbred mouse strains challenged with lipopolysaccharide (LPS) systemically. Thop could represent a potential sepsis biomarker or therapeutic target [2].

References

Families of protein phosphatase 1 modulators activated by protein kinases a and C: focus on brain. Liu, Q.R., Gong, J.P., Uhl, G.R. Prog. Nucleic. Acid. Res. Mol. Biol. (2005) [Pubmed]
Identification of novel genes that mediate innate immunity using inbred mice. Yang, I.V., Wade, C.M., Kang, H.M., Alper, S., Rutledge, H., Lackford, B., Eskin, E., Daly, M.J., Schwartz, D.A. Genetics. (2009) [Pubmed]

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