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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tmbim4  -  transmembrane BAX inhibitor motif...

Mus musculus

Synonyms: 0610007H07Rik, AU022431, Lfg4, Protein lifeguard 4, Transmembrane BAX inhibitor motif-containing protein 4, ...
 
 
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Disease relevance of Tmbim4

  • Alteration of additional factors other than accumulation of Z protein, for example inactivation of the endogenous mouse genes or some environmental challenge, might produce a mouse model with more relevance to neonatal liver disease [1].
 

High impact information on Tmbim4

  • Liver injury is caused by the accumulation of alpha(1)-AT mutant Z protein in hepatocytes, which triggers downstream intracellular injury pathways [2].
 

Analytical, diagnostic and therapeutic context of Tmbim4

References

  1. Evaluation of a transgenic mouse model for alpha-1-antitrypsin (AAT) related liver disease. Ali, R., Perfumo, S., della Rocca, C., Amicone, L., Pozzi, L., McCullagh, P., Millward-Sadler, H., Edwards, Y., Povey, S., Tripodi, M. Ann. Hum. Genet. (1994) [Pubmed]
  2. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Rudnick, D.A., Shikapwashya, O., Blomenkamp, K., Teckman, J.H. Hepatology (2006) [Pubmed]
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