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Gene Review

GRPEL1  -  GrpE-like 1, mitochondrial (E. coli)

Homo sapiens

Synonyms: FLJ25609, GREPEL1, GrpE protein homolog 1, mitochondrial, HMGE, Mt-GrpE#1
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Disease relevance of GRPEL1

  • Indeed, HMGE expressed in E. coli as a GST fusion protein co-purified with the E. coli Hsp70 protein DnaK in the absence of ATP [1].

Analytical, diagnostic and therapeutic context of GRPEL1

  • Subcellular fractionation and immunocytochemistry studies using antisera raized against HMGE show that it is a mitochondrial protein [1].


  1. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. Choglay, A.A., Chapple, J.P., Blatch, G.L., Cheetham, M.E. Gene (2001) [Pubmed]
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