The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

About

Terms

 

Gene Review: 

EFHD1  -  EF-hand domain family, member D1

Homo sapiens

Synonyms: EF-hand domain-containing protein 1, EF-hand domain-containing protein D1, FLJ13612, MST133, MSTP133, ...
 
 
 

High impact information on EFHD1

  • Mitocalcin is a mitochondrial Ca2+-binding protein with EF-hand and coiled-coil domains, and which associates with the inner mitochondrial membrane (immunogold electron microscopy) (mouse) [1].
  • Mitocalcin is expressed specifically in neurons but not in glial cells (mouse) [1].
  • Structure contains a disordered region at the N-terminus, followed by two EF-hands and a coiled-coil domain [2].
  • EFhd1 has been shown to bind calcium (mouse) [3].
  • Ectopic expression of manganese superoxide dismutase 2 (SOD2), a mitochondrial enzyme that inactivates superoxide to protect cells from oxidative damage, induces down-regulation of EFhd1 in a pancreatic carcinoma cell line. Conversely, reduction of SOD2 abundance causes increased EFhd1 expression in a human pancreatic carcinoma cell line (MIA-PaCa2) [4].
  • Myoblasts expressing CBP/p300 showed a 17-fold up-regulation of EFhd1 [5].

References

  1. Molecular characterization of mitocalcin, a novel mitochondrial Ca2+-binding protein with EF-hand and coiled-coil domains. Tominaga, M., Kurihara, H., Honda, S., Amakawa, G., Sakai, T., Tomooka, Y. J. Neurochem. (2006) [Pubmed]
  2. Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions. Dütting, S., Brachs, S., Mielenz, D. Cell. Commun. Signal. (2011) [Pubmed]
  3. Novel genes cloned from a neuronal cell line newly established from a cerebellum of an adult p53(-/-) mouse. Tominaga, M., Tomooka, Y. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  4. Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines. Hurt, E.M., Thomas, S.B., Peng, B., Farrar, W.L. Br. J. Cancer. (2007) [Pubmed]
  5. Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity. Kuninger, D., Wright, A., Rotwein, P. Am. J. Physiol. Cell. Physiol. (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities