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Gene Review

BRSK1  -  BR serine/threonine kinase 1

Homo sapiens

Synonyms: BR serine/threonine-protein kinase 1, Brain-selective kinase 1, Brain-specific serine/threonine-protein kinase 1, KIAA1811, SAD1, ...
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High impact information on BRSK1

  • Neither Bqt1 nor Bqt2 alone functions as a connector, but together the two proteins form a bridge between Rap1 (a telomere protein) and Sad1 (an SPB protein) [1].
  • In earlier work, we showed that Sad1, the gene encoding the first committed enzyme in the avenacin pathway (beta-amyrin synthase), had arisen by duplication and divergence of a cycloartenol synthase-like gene [2].
  • Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function [3].


  1. Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes. Chikashige, Y., Tsutsumi, C., Yamane, M., Okamasa, K., Haraguchi, T., Hiraoka, Y. Cell (2006) [Pubmed]
  2. A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense. Qi, X., Bakht, S., Qin, B., Leggett, M., Hemmings, A., Mellon, F., Eagles, J., Werck-Reichhart, D., Schaller, H., Lesot, A., Melton, R., Osbourn, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. Lu, R., Niida, H., Nakanishi, M. J. Biol. Chem. (2004) [Pubmed]
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