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Gene Review

MAP1LC3A  -  microtubule-associated protein 1 light...

Homo sapiens

Synonyms: ATG8E, Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, LC3, LC3A, ...
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High impact information on MAP1LC3A

  • MAP1LC3A and MAP1LC3C are produced by the proteolytic cleavage after the conserved C-terminal Gly residue, like their rat counterpart [1].
  • Protein kinase A mediated phosphorylation of MAP1LC3 inhibits its participation in autophagy, and protects against dendrite retraction in genetic (mutant LRRK2) and toxin (MPP+) models of Parkinson's disease. [2]



  1. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., Zhao, S., Liu, J.O., Yu, L. J. Biol. Chem. (2003) [Pubmed]
  2. Regulation of the autophagy protein LC3 by phosphorylation. Cherra SJ, 3.r.d., Kulich, S.M., Uechi, G., Balasubramani, M., Mountzouris, J., Day, B.W., Chu, C.T. J. Cell. Biol. (2010) [Pubmed]
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