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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HINT2  -  histidine triad nucleotide binding protein 2

Homo sapiens

Synonyms: HINT-2, HINT-3, HIT-17kDa, Histidine triad nucleotide-binding protein 2, mitochondrial, PKCI-1-related HIT protein
 
 
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Disease relevance of HINT2

 

Associations of HINT2 with chemical compounds

  • Hint2 overexpression in H295R cells had no effect on pregnenolone secretion elicited by angiotensin II or K+, whereas protein silencing with specific small interfering RNA resulted in a marked reduction of the steroidogenic response [2].

References

  1. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Martin, J., Magnino, F., Schmidt, K., Piguet, A.C., Lee, J.S., Semela, D., St-Pierre, M.V., Ziemiecki, A., Cassio, D., Brenner, C., Thorgeirsson, S.S., Dufour, J.F. Gastroenterology (2006) [Pubmed]
  2. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Lenglet, S., Antigny, F., Vetterli, L., Dufour, J.F., Rossier, M.F. Endocrinology (2008) [Pubmed]
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