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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CAF16  -  putative ATP-binding cassette family...

Saccharomyces cerevisiae S288c

Synonyms: CCR4-associated factor 16, YFL028C
 
 
 
 
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High impact information on CAF16

  • Mutations throughout the beta-sheet surface of the LRR, including those that did not specifically interfere with contacts to CAF1 or CAF16, significantly reduced CCR4 deadenylase activity [1].
 

Other interactions of CAF16

  • In contrast, CAF16, a potential ligand of CCR4, was abrogated in its binding to the LRR by mutations in the N terminus of the second beta-strand [1].

References

  1. Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. Clark, L.B., Viswanathan, P., Quigley, G., Chiang, Y.C., McMahon, J.S., Yao, G., Chen, J., Nelsbach, A., Denis, C.L. J. Biol. Chem. (2004) [Pubmed]
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