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Gene Review

LSM3  -  Lsm3p

Saccharomyces cerevisiae S288c

Synonyms: SMX4, SmX4 protein, U6 snRNA-associated Sm-like protein LSm3, USS2, YLR438C-A
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High impact information on LSM3

  • Surprisingly, using the tandem affinity purification (TAP) method, we identified Lsm1p among the subunits associated with Lsm3p [1].
  • Pre-U3 species were co-precipitated with TAP-tagged Lsm3p, but the association with spliced pre-U3 was lost in strains lacking Lhp1p [2].


  1. A Sm-like protein complex that participates in mRNA degradation. Bouveret, E., Rigaut, G., Shevchenko, A., Wilm, M., Séraphin, B. EMBO J. (2000) [Pubmed]
  2. A complex pathway for 3' processing of the yeast U3 snoRNA. Kufel, J., Allmang, C., Verdone, L., Beggs, J., Tollervey, D. Nucleic Acids Res. (2003) [Pubmed]
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