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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RNH202  -  Rnh202p

Saccharomyces cerevisiae S288c

Synonyms: RNase H(202), RNase H2 subunit B, Ribonuclease H2 subunit B, Ribonuclease HI subunit B, Rnh2B, ...
 
 
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High impact information on RNH202

  • Cells lacking RNH202 showed synthetic growth defects when combined with either mus81 or sgs1 alone [1].
  • But, whereas the loss of RAD51 had little effect on rnh202 sgs1 double mutants, it strongly inhibited the growth of rnh202 mus81 cells [1].
  • By affinity chromatography purification and identification of polypeptides associated with a tagged S.cerevisiae Rnh2Ap, we obtained a complex of three proteins [Rnh2Ap (Rnh201p), Ydr279p (Rnh202p) and Ylr154p (Rnh203p)] that together are necessary and sufficient for RNase H2 activity [correction] [2].

References

  1. Roles of SGS1, MUS81, and RAD51 in the repair of lagging-strand replication defects in Saccharomyces cerevisiae. Ii, M., Brill, S.J. Curr. Genet. (2005) [Pubmed]
  2. RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Jeong, H.S., Backlund, P.S., Chen, H.C., Karavanov, A.A., Crouch, R.J. Nucleic Acids Res. (2004) [Pubmed]
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