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Gene Review

VHS3  -  phosphopantothenoylcysteine decarboxylase...

Saccharomyces cerevisiae S288c

Synonyms: Phosphopantothenoylcysteine decarboxylase subunit VHS3, Viable in a HAL3 SIT4 background protein 3, YOR054C, YOR29-05
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High impact information on VHS3

  • The yeast gene VHS3 (YOR054c) has been recently identified as a multicopy suppressor of the G(1)/S cell cycle blockade of a conditional sit4 and hal3 mutant [1].
  • Phenotypic analyses using vhs3 mutants and overexpressing strains clearly show that Vhs3 has functions reminiscent to those of Hal3 and contrary to those of Ppz1 [1].
  • Vhs3 is structurally related to Hal3, a negative regulatory subunit of the Ser/Thr protein phosphatase Ppz1 important for cell integrity, salt tolerance, and cell cycle control [1].
  • Furthermore, a Vhs3 version carrying the H459A mutation did not rescue the synthetically lethal phenotype [1].

Other interactions of VHS3

  • These results indicate that, besides its role as Ppz1 inhibitory subunit, Vhs3 (and probably Hal3) might have important Ppz-independent functions [1].


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