The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

RPN8  -  proteasome regulatory particle lid subunit...

Saccharomyces cerevisiae S288c

Synonyms: 26S proteasome regulatory subunit RPN8, O5360, YOR261C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on RPN8

  • CSN6 haploinsufficiency restored growth, whereas reduction of proteasome subunits RPN8 or RPN11 had no effect [1].
  • We find that overexpression of WT (wild-type) RPN8, encoding a paralogous subunit that does not contain the catalytic MPN+ motif, corrects proteasome conformations and rescues cell cycle phenotypes, but is unable to correct defects in the mitochondrial tubular system or respiratory malfunctions associated with the mpr1-1 mutation [2].


  1. Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. Gemmill, R.M., Lee, J.P., Chamovitz, D.A., Segal, D., Hooper, J.E., Drabkin, H.A. Oncogene (2005) [Pubmed]
  2. Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain. Rinaldi, T., Pick, E., Gambadoro, A., Zilli, S., Maytal-Kivity, V., Frontali, L., Glickman, M.H. Biochem. J. (2004) [Pubmed]
WikiGenes - Universities