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Gene Review

TCO89  -  Tco89p

Saccharomyces cerevisiae S288c

Synonyms: 89 kDa TOR complex 1 protein, TORC1 subunit TCO89, Target of rapamycin complex 1 subunit TCO89, YPL180W
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High impact information on TCO89

  • Deletion of TOR1 or TCO89 results in two specific and distinct phenotypes, (i) rapamycin-hypersensitivity and (ii) decreased cellular integrity, both of which correlate with the presence of SSD1-d, an allele of SSD1 previously associated with defects in cellular integrity [1].
  • In particular, we have identified Tco89p (YPL180w) and Bit61p (YJL058c) as novel components of TORC1 and TORC2, respectively [1].


  1. TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. Reinke, A., Anderson, S., McCaffery, J.M., Yates, J., Aronova, S., Chu, S., Fairclough, S., Iverson, C., Wedaman, K.P., Powers, T. J. Biol. Chem. (2004) [Pubmed]
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