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Gene Review:

yaeL - zinc metalloprotease

Chlamydia trachomatis D/UW-3/CX

Balakrishnan, A. et al.

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Disease relevance of yaeL

Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium [1].

High impact information on yaeL

Nucleotide sequences of candidate metalloprotease genes remained unchanged in a chlamydial variant designated GR10, which had been selected for resistance to the inhibitors [1].

References

Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. Balakrishnan, A., Patel, B., Sieber, S.A., Chen, D., Pachikara, N., Zhong, G., Cravatt, B.F., Fan, H. J. Biol. Chem. (2006) [Pubmed]

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