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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

eccCb1  -  ESX-1 secretion system protein EccCb

Mycobacterium tuberculosis H37Rv

 
 
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Disease relevance of Rv3871

 

High impact information on Rv3871

  • Point mutations in the signal that abolished binding of CFP-10 to Rv3871 prevented secretion of the CFP-10 (culture filtrate protein, 10 kilodaltons)/ESAT-6 virulence factor complex [2].
 

Analytical, diagnostic and therapeutic context of Rv3871

  • DESIGN: Serum from 300 Gambians (100 with active PTB, 100 of their household contacts, and 100 community controls) was tested using an ELISA method to detect antibodies to seven mycobacterial antigens (three encoded in the RD-1 region [ESAT-6, CFP-10 and Rv3871] and four common [38 kDa, GLU-S, 19 kDa and 14 kDa]) [3].

References

  1. Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome. Brusasca, P.N., Colangeli, R., Lyashchenko, K.P., Zhao, X., Vogelstein, M., Spencer, J.S., McMurray, D.N., Gennaro, M.L. Scand. J. Immunol. (2001) [Pubmed]
  2. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Champion, P.A., Stanley, S.A., Champion, M.M., Brown, E.J., Cox, J.S. Science (2006) [Pubmed]
  3. Humoral response to Mycobacterium tuberculosis antigens in patients with tuberculosis in the Gambia. Greenaway, C., Lienhardt, C., Adegbola, R., Brusasca, P., McAdam, K., Menzies, D. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (2005) [Pubmed]
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