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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAP3K6  -  mitogen-activated protein kinase kinase...

Homo sapiens

Synonyms: ASK2, Apoptosis signal-regulating kinase 2, MAPKKK6, MEKK6, Mitogen-activated protein kinase kinase kinase 6
 
 
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High impact information on MAP3K6

  • In both genotypes expression of Ask2 (monofunctional Asp-kinase-2), Akh1 and Akh2 (bifunctional Asp-kinase-homo-Ser dehydrogenase-1 and 2), increased throughout germination and post-germination growth, suggesting a developmental regulation, whereas Ask1 (monofunctional Asp-kinase-1) was expressed constitutively [1].
 

Other interactions of MAP3K6

  • This novel protein is predicted to contain all 11 kinase subdomains and shares 45% amino acid identity with MAPKKK5 and thus is designated MAPKKK6 [2].

References

  1. Physiological and molecular aspects of aspartate-derived amino acid metabolism during germination and post-germination growth in two maize genotypes differing in germination efficiency. Anzala, F., Morère-Le Paven, M.C., Fournier, S., Rondeau, D., Limami, A.M. J. Exp. Bot. (2006) [Pubmed]
  2. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. Wang, X.S., Diener, K., Tan, T.H., Yao, Z. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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