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Gene Review:

pgpA - phosphatidylglycerophosphatase A

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0412, JW0408, yajN

Icho, T. et al., Icho, T.

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Disease relevance of pgpA

Membrane-bound phosphatases in Escherichia coli: sequence of the pgpA gene [1].

High impact information on pgpA

One of the phosphatidyl glycerophosphate phosphatase genes of Escherichia coli, pgpA, was cloned, and its DNA sequence was determined [1].
The pgpA gene product is specific for PGP, whereas the pgpB gene product also acts on phosphatidic acid and lysophosphatidic acid [2].
The available mutant alleles of pgpA reduced the specific activity of PGP phosphatase in crude extracts by about 30%, but they had no effect on phosphatidic acid (or lysophosphatidic acid) phosphatase [2].

References

Membrane-bound phosphatases in Escherichia coli: sequence of the pgpA gene. Icho, T. J. Bacteriol. (1988) [Pubmed]
Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors. Icho, T., Raetz, C.R. J. Bacteriol. (1983) [Pubmed]

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