Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

hinT - purine nucleoside phosphoramidase, dadA...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1089, JW1089, ycfF

Chou, T.F. et al.

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Disease relevance of hinT

Analysis of the lysates from a constructed hinT knock-out strain of E. coli demonstrated that all of the cellular purine nucleoside phosphoramidase activity is due to hinT [1].

High impact information on hinT

Thus, cation-resistant bacterial cell growth may be dependent on the hydrolysis of adenylylated and/or guanylylated phosphoramidate substrates by hinT [1].

References

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions. Chou, T.F., Bieganowski, P., Shilinski, K., Cheng, J., Brenner, C., Wagner, C.R. J. Biol. Chem. (2005) [Pubmed]

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