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Gene Review

SEC22B  -  SEC22 vesicle trafficking protein homolog...

Homo sapiens

Synonyms: ER-Golgi SNARE of 24 kDa, ERS-24, ERS24, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, ...
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High impact information on SEC22B

  • Both proteins also share structural similarity with the amino-terminal regulatory domains of the membrane trafficking proteins, sec22b and Ykt6p, as well as with sedlin (a component of a Golgi-associated membrane-trafficking complex) and the sigma2 and amino-terminal portion of the mu2 subunits of the clathrin adaptor complex AP2 [1].
  • The open reading frame encodes a polypeptide of 250 amino acids which is homologous to, but obviously different from, the recently reported mammalian Sec22p homologs rat sec22a, mouse sec22b, and hamster ERS-24 [2].


  1. The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling. Lunin, V.V., Munger, C., Wagner, J., Ye, Z., Cygler, M., Sacher, M. J. Biol. Chem. (2004) [Pubmed]
  2. Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24. Tang, B.L., Low, D.Y., Hong, W. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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