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Ouimet, N. et al.

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.

Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl-2-thiazolylthio)-5-methanesulfonamido-3H-isobe nzofuran-1-one 14 was found to be the optimal compound in the series with superior in vitro and in vivo activities.[1]

References

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class. Ouimet, N., Chan, C.C., Charleson, S., Claveau, D., Gordon, R., Guay, D., Li, C.S., Ouellet, M., Percival, D.M., Riendeau, D., Wong, E., Zamboni, R., Prasit, P. Bioorg. Med. Chem. Lett. (1999) [Pubmed]

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