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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Costimulatory regulation of T cell function.

During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.[1]


  1. Costimulatory regulation of T cell function. Chambers, C.A., Allison, J.P. Curr. Opin. Cell Biol. (1999) [Pubmed]
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