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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Colony stimulating factor-inducing activity of hesperidin.

To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6 h before bleeding. All compounds carrying the glucosyl-rhamnose moiety showed potent activity. Among them, hesperidin exhibited the strongest activity. Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later. The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.[1]


  1. Colony stimulating factor-inducing activity of hesperidin. Kawaguchi, K., Kikuchi, S., Takayanagi, K., Yoshikawa, T., Kumazawa, Y. Planta Med. (1999) [Pubmed]
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