Nuclear bodies: multifaceted subdomains of the interchromatin space.
Higher-eukaryotic nuclei contain numerous morphologically distinct substructures that are collectively called nuclear bodies. Although the precise functions of these subdomains remain unknown, elucidation of their molecular composition has been the subject of a great deal of research in recent years. Changes in the constitution of these nuclear inclusions are associated with disease phenotypes. The wide variety of components that concentrate within these subdomains makes them a likely interface for multiple cellular processes, including transcription, RNA processing, transport, RNP assembly, protein modification, apoptosis and cell-cycle control. This review discusses the different types of nuclear bodies, with emphasis on the two most prominent subtypes - the coiled and PML bodies.[1]References
- Nuclear bodies: multifaceted subdomains of the interchromatin space. Matera, A.G. Trends Cell Biol. (1999) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
