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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Revision of the stereochemistry of batzelladine F. Approaches to the tricyclic hydroxyguanidine moiety of batzelladines G, H, and I.

The polycyclic guanidine alkaloids batzelladines F-I isolated from a Jamaican sponge of the genus Batzella in 1997 are of potential value for the treatment of AIDS because they induce p56lck-CD4 dissociation at micromolar concentrations. Comparison of the spectral data for both the synthetic syn and anti tricyclic left-hand portions of batzelladine F establishes that the natural product has the syn rather than the anti stereochemistry originally assigned. Approaches to the tricyclic hydroxyguanidine moiety of batzelladines G-I are described.[1]

References

  1. Revision of the stereochemistry of batzelladine F. Approaches to the tricyclic hydroxyguanidine moiety of batzelladines G, H, and I. Snider, B.B., Busuyek, M.V. J. Nat. Prod. (1999) [Pubmed]
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