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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The 5-HT(1A) antagonist WAY 100635 can block the low-dose locomotor stimulant effects of cocaine.

Cocaine treatments of 2.5, 5.0, 10.0 and 15.0 mg/kg induced dose-dependent increases in locomotor behavior. This cocaine-induced increase in locomotion was blocked if the animals were administered the selective 5-HT(1A) antagonist, WAY 100635 (0.4 mg/kg) prior to the cocaine treatment. The 0.4-mg/kg dose of WAY 100635 did not affect locomotor behavior or alter cocaine availability in brain.[1]


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