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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The 26S proteasome: ubiquitin-mediated proteolysis in the tunnel.

The 26S proteasome is a self-compartmentalizing protease responsible for the degradation of intracellular proteins. This giant intracellular protease is formed by several subunits arranged into two 19S polar caps-where protein recognition and ATP-dependent unfolding occur-flanking a 20S central barrel-shaped structure with an inner proteolytic chamber. Proteins targeted to the 26S proteasome are conjugated with a polyubiquitin chain by an enzymatic cascade before delivery to the 26S proteasome for degradation into oligopeptides. As a self-compartmentalizing protease, the 26S proteasome circumvents proteins not destined for degradation and can be deployed to the cytoplasmic and nuclear compartments. The 26S proteasome is a representative of emerging group of giant proteases, including tricorn protease, multicorn protease, and TPPII (tripeptidyl peptidase II).[1]


  1. The 26S proteasome: ubiquitin-mediated proteolysis in the tunnel. Kierszenbaum, A.L. Mol. Reprod. Dev. (2000) [Pubmed]
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