Expression of leukemia inhibitory factor in the ganglionic eminence of the human fetal brain after bleedings.
Bleedings in the ganglionic eminence (GE) being a prominent domain of the telencephalic proliferative zone is a frequent complication of preterm infants. Such bleedings may induce cellular responses in the vicinity of the lesion. Using immunohistochemistry, this study demonstrates for the first time that leukemia inhibitory factor ( LIF) belonging to the family of neuropoetic cytokines is expressed in GE cells up to 200 microm from the lesion (six brains, gestational age 22-26 weeks); whereas control brains do not exhibit any LIF-immunoreactive cells in the GE. The expression of LIF in cases with bleedings may interfere with normal developmental processes taking place within the ganglionic eminence.[1]References
- Expression of leukemia inhibitory factor in the ganglionic eminence of the human fetal brain after bleedings. Ulfig, N. Neurosci. Lett. (2001) [Pubmed]
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