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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Nicorandil can induce severe oral ulceration.

OBJECTIVE: To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration. STUDY DESIGN: Nine new cases of ulceration from 3 European countries were included in this study. RESULTS: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia. CONCLUSIONS: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.[1]

References

  1. Nicorandil can induce severe oral ulceration. Scully, C., Azul, A.M., Crighton, A., Felix, D., Field, A., Porter, S.R. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2001) [Pubmed]
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