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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Cbl: many adaptations to regulate protein tyrosine kinases.

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?[1]

References

  1. Cbl: many adaptations to regulate protein tyrosine kinases. Thien, C.B., Langdon, W.Y. Nat. Rev. Mol. Cell Biol. (2001) [Pubmed]
 
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