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Discotto, L.F. et al.

Discotto, Lawrence, Denbleyker, Barrett,

Staphylococcus aureus mutants selected by BMS-284756.

BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitro mutants of Staphylococcus aureus ISP794. Step mutants were obtained, and the quinolone resistance-determining regions of four target genes, gyrA, gyrB, grlA, and grlB, were sequenced. The data suggest that DNA gyrase is the primary target for BMS-284756 in S. aureus.[1]

References

Staphylococcus aureus mutants selected by BMS-284756. Discotto, L.F., Lawrence, L.E., Denbleyker, K.L., Barrett, J.F. Antimicrob. Agents Chemother. (2001) [Pubmed]

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