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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren's syndrome.

Secretions from salivary and lacrimal glands are reduced in patients with primary Sjögren's syndrome (PSS). Since aquaporin 5 is involved in transport of water and is present in salivary and lacrimal glands, this protein was thought to have a major role in the pathogenesis of PSS. We used indirect immunofluorescence and an immunoperoxidase technique to assess expression and subcellular localisation of aquaporin 5 in patients and controls. Our results suggest that the distribution and density of aquaporin 5 in salivary glands does not differ between patients with PSS and those without. Thus, the role of aquaporin 5 in the pathogenesis of PSS needs to be reassessed and alternative pathogenetic mechanisms investigated.[1]

References

  1. Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren's syndrome. Beroukas, D., Hiscock, J., Jonsson, R., Waterman, S.A., Gordon, T.P. Lancet (2001) [Pubmed]
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