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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Schmidt, L.G. et al.

Schmidt, Samochowiec, Finckh, Fiszer-Piosik, Horodnicki, Wendel, Rommelspacher, Hoehe,

Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence.

Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNR1) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls. The observed frequency of the A allele was 31.2% for controls and 42.1% for alcoholics with severe withdrawal syndromes (P=0.010). Post-hoc exploration indicated that this allelic association resulted from an excess of the homozygous A/A genotype in patients with a history of alcohol delirium (P=0.031, DF 2), suggesting s an increased risk of delirium (OR=2.45, 95% CI 1.14--5.25). This finding suggests that the homozygous genotype CNR1 1359A/A confers vulnerability to alcohol withdrawal delirium.[1]

References

Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Schmidt, L.G., Samochowiec, J., Finckh, U., Fiszer-Piosik, E., Horodnicki, J., Wendel, B., Rommelspacher, H., Hoehe, M.R. Drug and alcohol dependence. (2002) [Pubmed]

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