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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast.

Yra1p is an essential and conserved mRNA export factor in yeast. Strikingly, removal of the intron from YRA1 causes a dominant-negative growth phenotype and a concomitant inhibition of mRNA export. However, both defects are neutralized by replacement of the intron of YRA1 by a different intron. Significantly, Yra1p is overproduced in yeast when expressed from its intronless gene, but Yra1p levels are the same as the wild type when expressed from an intron-containing YRA1 gene. Thus, an intron in YRA1 controls Yra1p expression and mRNA export.[1]

References

  1. An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast. Rodríguez-Navarro, S., Strässer, K., Hurt, E. EMBO Rep. (2002) [Pubmed]
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