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One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.

Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.[1]

References

  1. One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization. Flynn, B.L., Hamel, E., Jung, M.K. J. Med. Chem. (2002) [Pubmed]
 
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