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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

CFC index for the diagnosis of cardiofaciocutaneous syndrome.

Controversy exists concerning the delineation of cardiofaciocutaneous syndrome (CFC). Many authors have attempted to establish syndrome traits for CFC, but to date none are pathognomonic or obligatory. We have created a clinical and objective method, called the CFC index, for CFC diagnosis. This method also differentiates CFC from Noonan syndrome and Costello syndrome, CFC's main differential diagnosis. We propose the use of the CFC index for the confirmation of CFC diagnosis and to differentiate CFC from other phenotypically similar genetic conditions, while molecular studies are still in progress.[1]


  1. CFC index for the diagnosis of cardiofaciocutaneous syndrome. Kavamura, M.I., Peres, C.A., Alchorne, M.M., Brunoni, D. Am. J. Med. Genet. (2002) [Pubmed]
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