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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Post-translational modification of barley 14-3-3A is isoform-specific and involves removal of the hypervariable C-terminus.

The 14-3-3 protein family is a family of regulatory proteins involved in diverse cellular processes. In a previous study of regulation of individual 14-3-3 isoforms in the germinating barley embryo, we found that a post-translationally modified, 28 kDa form of 14-3-3A was present in specific cell fractions of the germinated embryo. In the present study, we identify the nature of the modification of 14-3-3A, and show that the 28 kDa doublet is the result of cleavage of the C-terminus. The 28 kDa forms of 14-3-3A lack ten or twelve amino acid residues at the non-conserved C-terminus of the protein, respectively. Barley 14-3-3B and 14-3-3C are not modified in a similar way. Like the 30 kDa form, in vitro produced 28 kDa 14-3-3A is still capable of binding AHA2 H+-ATPase in an overlay assay. Our results show a novel isoform-specific post-translational modification of 14-3-3 proteins that is regulated in a tissue-specific and developmental way.[1]

References

  1. Post-translational modification of barley 14-3-3A is isoform-specific and involves removal of the hypervariable C-terminus. Testerink, C., van Zeijl, M.J., Drumm, K., Palmgren, M.G., Collinge, D.B., Kijne, J.W., Wang, M. Plant Mol. Biol. (2002) [Pubmed]
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