- RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. Casey, G., Neville, P.J., Plummer, S.J., Xiang, Y., Krumroy, L.M., Klein, E.A., Catalona, W.J., Nupponen, N., Carpten, J.D., Trent, J.M., Silverman, R.H., Witte, J.S. Nat. Genet. (2002)