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Ohguchi, K. et al.

Ohguchi, Tanaka, Iliya, Ito, Iinuma, Matsumoto, Akao, Nozawa,

Gnetol as a potent tyrosinase inhibitor from genus Gnetum.

Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.[1]

References

Gnetol as a potent tyrosinase inhibitor from genus Gnetum. Ohguchi, K., Tanaka, T., Iliya, I., Ito, T., Iinuma, M., Matsumoto, K., Akao, Y., Nozawa, Y. Biosci. Biotechnol. Biochem. (2003) [Pubmed]

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