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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of calcium carbonate on bioavailability of orally administered gemifloxacin.

We investigated the effect of calcium carbonate on the oral bioavailability of gemifloxacin. Gemifloxacin was administered alone, 2 h before, simultaneously, or 2 h after calcium carbonate in 16 volunteers. Data for 320 mg of gemifloxacin alone were as follows: maximum concentration of drug in serum (C(max)),13 microg/ml; half-life, 7.33 h; and area under the concentration-time curve from 0 h to infinity (AUC( infinity )), 6.79 microg. h/ml. Only simultaneous coadministration of calcium carbonate reduced C(max) (-17%) and AUC( infinity ) (-21%) significantly.[1]


  1. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Pletz, M.W., Petzold, P., Allen, A., Burkhardt, O., Lode, H. Antimicrob. Agents Chemother. (2003) [Pubmed]
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