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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs.

The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.[1]


  1. Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs. Perry, E.K., Kilford, L., Lees, A.J., Burn, D.J., Perry, R.H. Ann. Neurol. (2003) [Pubmed]
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