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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Dynamic release of Cdc34 from SCF. the hand that rocks the cradle.

Polyubiquitylation is a complex but poorly understood biochemical reaction catalyzed by E3 ubiquitin ligases. In this issue of Cell, Deffenbaugh et al. provide experimental support for a model in which the dynamic release of the ubiquitin-charged E2 Cdc34 from its primary binding site within the rigid cradle-like SCF E3 complex allows for unexpected spatial flexibility to assemble a polyubiquitin chain.[1]

References

  1. Dynamic release of Cdc34 from SCF. the hand that rocks the cradle. Wolf, D.A., Geyer, R. Cell (2003) [Pubmed]
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