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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neuregulin 1-alpha expression in locally advanced breast cancer.

The human Neuregulin 1 (NRG1) gene encodes several alternatively spliced ligands that bind to both c-erbB-3 and c-erbB-4, members of the family of type 1 tyrosine kinase growth factor receptors. Antibodies raised to a synthetic peptide recognize selectively the alpha variant of NRG1. The NRG1-alpha isoforms' expression was studied in 115 locally advanced adenocarcinomas of the breast using immunohistochemistry. Absent or low levels of NRG1-alpha were found to be associated with poorer prognosis compared to tumours that had moderate to high levels of the protein.[1]


  1. Neuregulin 1-alpha expression in locally advanced breast cancer. Raj, E.H., Skinner, A., Mahji, U., Nirmala, K.N., Ravichandran, K., Shanta, V., Hurst, H.C., Gullick, W.J., Rajkumar, T. Breast (Edinburgh, Scotland) (2001) [Pubmed]
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