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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Riendeau, D. et al.

Riendeau, Salem, Styhler, Ouellet, Mancini, Li,

Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.

Loxoprofen, its trans-alcohol and cis-alcohol metabolites were evaluated for selectivity of inhibition of COX-2 over COX-1. The (2S,1'R,2'S)-trans-alcohol derivative was found to be the most active metabolite and to be a potent and nonselective inhibitor of COX-2 and COX-1 in both enzyme and human whole blood assays.[1]

References

Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Riendeau, D., Salem, M., Styhler, A., Ouellet, M., Mancini, J.A., Li, C.S. Bioorg. Med. Chem. Lett. (2004) [Pubmed]

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