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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720.

A chemo- and regioselective cross-coupling reaction of the functionalized aryl triflate 5 with octylmagnesium bromide catalyzed by cheap, nontoxic, and environmentally benign Fe(acac)(3) sets the basis for a practical and scaleable synthesis of the octylbenzene derivative 6, which serves as a key building block for the preparation of FTY720 (1). This 2-amino-1,3-propanediol derivative shows highly promising immunosuppressive properties and is currently in human clinical phase III trials.[1]

References

  1. Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720. Seidel, G., Laurich, D., Fürstner, A. J. Org. Chem. (2004) [Pubmed]
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