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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Nauseef, W.M.

Nauseef,

Lessons from MPO deficiency about functionally important structural features.

Genetic abnormalities often serve as the catalyst to stimulate critical insights into normal biology. In many cases, examining such experiments of Nature explicates not only the abnormal but also serves to illustrate underlying normal principles. Within the context of myeloperoxidase biosynthesis, we have examined the impact of specific missense mutations that cause inherited myeloperoxidase deficiency. Such studies have provided novel insights not otherwise possible. We have described three such mutations and are completing the analysis of a fourth.[1]

References

Lessons from MPO deficiency about functionally important structural features. Nauseef, W.M. Jpn. J. Infect. Dis. (2004) [Pubmed]

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